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Unni Grimholt

Name:	Unni Grimholt
Title:	Researcher
Memo:
E-mail:	unni.grimholt@veths.no
Phone:	22 96 47 87
Other publications:	[click here]

Research diciplines related to Aquamedicine:
Education, Genetics and Immunology.
Projects related to Aquamedicine:
Characterization of virulence factors of importance for infectious salmon anaemia. Experimental trials
Development of a pathogen epitope prediction programme and evaluating its usefulness in designing fish vaccines
Evaluation of MHC genes as quantitative trait loci (QTLs) for disease resistance in fish
Experimental Atlantic salmon and cod resources
Expression and function of disease related genes in Atlantic salmon
Marker-assisted selection for IPN-resistance in Atlantic salmon
Molecular mechanisms of viral disease in Atlantic salmon (Salmo salar L.)
Sequence and function of immune genes in marine species
Use of MHC-genes in marker assisted selection for increased disease resistance in Atlantic salmon
Publications related to Aquamedicine:
2007
Glover K.A., Grimholt U., Bakke H.G., Nilsen F., Storset A., Skaala Ø. (2007) Major histocompatibility complex (MHC) variation and susceptibility to the sea louse Lepeophtheirus. Diseases of Aquatic Organisms.
Jørgense SM, Grimholt U, Gjøen T (2007) Cloning and expression analysis of an Atlantic salmon (Salmo salar L.) tapasin gene. Dev Comp Immunol.
Jørgensen S.M., Lem Hetland D., Press C.McL., Grimholt U., Gjøen T. (2007) Effect of early infectious salmon anemia virus (ISAV) infection on expression of MHC. Fish and Shellfish Immunology.
Lukacs M., Harstad H., Grimholt U., Beetz-Sargent M., Cooper G.A.,Reid L., Bakke H.G., Phillips R., Miller K.M., Davidson W., Koop B. (2007) Genomic organization of duplicated major histocompatibility complex class I regions in Atlantic salmon. BMC Genomics.
2006
Jørgensen SM, Kleveland E-J, Grimholt U, Gjøen T (2006) Validation of reference genes for real-time PCR studies in Atlantic salmon. Marine Biotechnology 8;398-408.
Jørgensen SM, Kleveland E-J, Grimholt U, Gjøen T (2006) Validation of reference genes for real-time PCR studies in Atlantic salmon. Marine Biotechnology 8;398-408.
Jørgensen SM, Lyng-Syvertsen B, Lukacs M, Grimholt U, Gjøen T (2006) Expression of MHC class I pathway genes in response to infectious salmon anaemia virus in Atlantic salmon (Salmo salar L.) cells.. Fish and Shellfish Immunology 21;548-560.
Kjøglum S, Larsen S, Grimholt U (2006) How spesific MHC class I and class II combnations affect resistance against ISAV in Atlantic salmon. Fish and Shellfish Immunology 21;431-441.
2005
Mjaaland S., Markussen T, Sindre H, Kjøglum S, Dannevig BH, Larsen S, Grimholt U (2005) Susceptibility and immune responses following experimental infection of MHC compatible Atlantic salmon (Salmo salar L.) with different infectious salmon anaemia virus (ISAV) isolates. Archives of virology 150;2195-2216.
Sissel Kjøglum, Unni Grimholt, Stig Larsen (2005) Quantification of the genetic non-MHC effect and tank effect influencing challenge trials in Atlantic salmon. Aquaculture 250;102-109.
2003
Grimholt, U, Stig Larsen, Rolf Nordmo, Paul J. Midtlyng, Sissel Kjøglum, Arne Storset, Solve Sæbø, René J.M. Stet (2003) MHC polymorphism and disease resistance in Atlantic salmon (Salmo salar); Facing pathogens with single expressed Major histocompatibility class I and class II loci. Immunogenetics 55; 210-219.
2002
Grimholt, U., Finn Drabløs, Sven Martin Jørgensen, Bjørn Høyheim, René J.M.Stet (2002) The Major Histocompatibility Class I locus in Atlantic salmon (Salmo salar L.): Polymorphism, linkage analysis and protein modelling. Immunogenetics 54;570-581.
Stet, R.J.M., Beja de vries, Karin Mudde, Trudi T. Hermsen, Joost van Heerwaarden, Benny P. Shum, Unni Grimholt (2002) Unique haplotypes of co-segregating MHC class II A and class II B alleles in Atlantic salmon (Salmo salar) give rise to diverse class II genotypes. Immunogenetics 54;320-331.
2000
Grimholt, U., A.Getahun, T.Hermsen, R.J.M.Stet (2000) The Major Histocompatibility Class II Alpha chain in Salmonid Fishes. Dev.Comp.Immunol.24:751-763.
1998
Grimholt, U., Lie, Ø. (1998) Mhc in fish. In: Genetic resistance to animals diseases; Major histocompatibility complex in ruminants.Eds. M.Muller and G Brem. OIE Scientific and Technical Review, vol.17(1):121-127.
Lie, Ø., Grimholt, U. (1998) "Immunology of fishes. Major histocompatibility complex".. In: Handbook of Vertebrate Immunology. Section: Immunology of Fishes. Eds. Pastoret, P.P., Griebel, P., Bazin, H. and Govaerts, H. Academic Press Limited, 23-25.
1997
Grimholt, U. (1997) Transport-associated proteins in Atlantic salmon (Salmo salar). Immunogenetics 46:213-221.
Grimholt, U., Olsaker, I., Lingaas, F. and Lie, Ø. (1997) Sequence analysis of MHC class I a2 domain exon variants in one diploid and two haploid Atlantic salmon pedigrees. Animal Genetics 28:385-390.
1996
Lie, Ø. and Grimholt, U (1996) The major histocompatibility complex of fish: Genetic Structure and Function of the Major Histocompatibility Complex of Teleost Species. n: The Major Histocompatibility Complex Region of Domestic Animal Species. Eds. L.Schook and S.Lamon.
1994
Grimholt, U., Olsaker, I., and Lie, Ø (1994) A study on variation in the beta 1 and alpha 2 domain exons of Atlantic salmon. Animal Genetics 25:147-153.
Lie, Ø., Slettan, A., Grimholt, U., Lundin, M., Syed, M., and Olsaker, I (1994) Fish gene maps and their implications for aquaculture. Animal Biotechnol. 5:209-218.
1993
Grimholt, U., I.Hordvik, V.M.Fosse, I.Olsaker, C.Endresen and Øystein Lie (1993) Molecular cloning of major histocompatibility complex class I cDNAs from Atlantic salmon (Salmo salar). Immunogenetics 37:469-473.
Hordvik, I., U.Grimholt, V.M.Fosse, Ø.Lie and C.Endresen (1993) Cloning and sequence analysis of cDNAs encoding the Mhc class II alpha chain in Atlantic salmon, Salmo salar. Immunogenetics 37:437-441.

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Unni Grimholt

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